(a)
Schedule I shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it.
(b)
Opiates. Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation (for purposes of paragraph (b)(34) only, the term isomer includes the optical and geometric isomers):
(4)
Alphacetylmethadol (except /levo-Alphacetylmethadol also known as /levo-Alpha-acetylmethadol, Levomethadyl acetate, or LAAM)
9603
(7)
Alpha-methylfentanyl (
N-[1-(Alpha-methyl-beta-phenyl)ethyl-4-piperidyl]propionanilide; 1-(1-Methyl-2-phenylethyl)-4-(
N-propanilido)piperidine)
9814
(34)
3-Methylfentanyl (
N-[3-Methyl-1-(2-phenylethyl)-4-piperidyl]-
N-phenylpropanamide)
9813
(37)
MPPP (1-Methyl-4-phenyl-4-propionoxypiperidine)
9661
(43)
PEPAP (1-(-2-Phenethyl)-4-phenyl-4-acetoxypiperidine)
9663
(53)
Thiofentanyl (
N-Phenyl-
N-[1-(2-thienyl)ethyl-4-piperidinyl]propanamide)
9835
(c)
Opium derivatives. Unless specifically excepted or unless listed in another schedule, any of the following opium derivatives, its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
(d)
Hallucinogenic substances. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation (for purposes of this paragraph only, the term “isomer” includes the optical, position and geometric isomers):
(1)
Alpha-ethyltryptamine (Etryptamine; Monase; α-Ethyl-1
H-indole-3-ethanamine; 3-(2-Aminobutyl)indole; α-ET; AET)
7249
(17)
Bufotenine (3-(β-Dimethylaminoethyl)-5-hydroxyindole; 3-(2-Dimethylaminoethyl)-5-indolol;
N,
N-Dimethylserotonin; 5-Hydroxy-
N,
N-dimethyltryptamine; Mappine)
7433
(21)
Ibogaine (7-Ethyl-6,6β,7,8,9,10,12,13-octahydro-2-methoxy-6,9-methano-5
H-pyrido[1ʹ,2ʹ:1,2]azepino[5,4-
b]indole;
Tabernanthe iboga)
7260
(25)
Parahexyl (3-Hexyl-1-hydroxy-7,8,9,10-tetrahydro-6,6,9-trimethyl-6
H-dibenzo[
b,
d]pyran; Synhexyl)
7374
(31)
Tetrahydrocannabinols Meaning
Tetrahydrocannabinols naturally contained in a plant of the genus Cannabis (cannabis plant), as well as synthetic equivalents of the substances contained in the cannabis plant, or in the resinous extractives of such plant, and\/or synthetic substances, derivatives, and their isomers with similar chemical structure and pharmacological activity to those substances contained in the plant, such as the following:
(e)
Depressants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
(1)
Gamma-hydroxybutyric acid (GHB; Gamma-hydroxybutyrate; 4-Hydroxybutyrate; 4-Hydroxybutanoic acid; Sodium oxybate; Sodium oxybutyrate)
2010
(f)
Stimulants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers, and salts of isomers:
(1)
Aminorex (Aminoxaphen; 2-Amino-5-phenyl-2-oxazoline; 4,5-Dihydro-5-phenyl-2-oxazolamine)
1585
(2)
N-Benzylpiperazine (BZP; 1-Benzylpiperazine), its optical isomers, salts and salts of isomers
7493
(3)
Cathinone (2-Amino-1-phenyl-1-propanone; Alpha-aminopropiophenone; 2-Aminopropiophenone; Norephedrone)
1235
(5)
Methcathinone (2-(Methylamino)propiophenone; Alpha-(methylamino)propiophenone; 2-(Methylamino)-1-phenylpropan-1-one; Alpha-
N-methylaminopropiophenone; Monomethylpropion; Ephedrone;
N-Methylcathinone; Methylcathinone; AL-464; AL-422; AL-463; UR1432), its salts, optical isomers and salts of optical isomers
1237
(g)
Cannabimimetic Agents. Unless specifically exempted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of cannabimimetic agents, or which contains their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation.
(A)
The term ‘cannabimimetic agents’ means any substance that is a cannabinoid receptor type 1 (CB1 receptor) agonist as demonstrated by binding studies and functional assays within any of the following structural classes:
(i)
2-(3-Hydroxycyclohexyl)phenol with substitution at the 5-position of the phenolic ring by alkyl or alkenyl, whether or not substituted on the cyclohexyl ring to any extent.
(ii)
3-(1-Naphthoyl)indole or
3-(1-Naphthylmethane)indole by substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent, whether or not substituted on the naphthoyl or naphthyl ring to any extent.
(iii)
3-(1-Naphthoyl)pyrrole by substitution at the nitrogen atom of the pyrrole ring, whether or not further substituted in the pyrrole ring to any extent, whether or not substituted on the naphthoyl ring to any extent.
(iv)
1-(1-Naphthylmethylene)indene by substitution of the 3-position of the indene ring, whether or not further substituted in the indene ring to any extent, whether or not substituted on the naphthyl ring to any extent.
(v)
3-Phenylacetylindole or
3-Benzoylindole by substitution at the nitrogen atom of the indole ring, whether or not further substituted in the indole ring to any extent, whether or not substituted on the phenyl ring to any extent.
(h)
Temporary listing of substances subject to emergency scheduling. Any material, compound, mixture or preparation which contains any quantity of the following substances:
(1)
(1-Pentyl-1H-indol-3-yl)(2,2,3,3-
tetramethylcyclopropyl)methanone (UR-144; 1-Pentyl-3-(2,2,3,3-tetramethylcyclopropoyl)indole), its optical, positional, and geometric isomers, salts and salts of isomers
7144
(2)
[1-(5-Fluoro-pentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone (5-Fluoro-UR-144; 5-F-UR-144; XLR11; 1-(5-Fluoro-pentyl)-3-(2,2,3,3-tetramethylcyclopropoyl)indole), its optical, positional, and geometric isomers, salts and salts of isomers
7011
(11)
4-Methyl-N-ethylcathinone (4-MEC; 2-(Ethylamino)-1-(4-methylphenyl)propan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
1249
(12)
4-Methyl-alpha-pyrrolidinopropiophenone (4-MePPP; MePPP; 4-Methyl-α-pyrrolidinopropiophenone; 1-(4-Methylphenyl)-2-(pyrrolidin-1-yl)-propan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
7498
(13)
alpha-Pyrrolidinopentiophenone (α-PVP; α-Pyrrolidinopentiophenone; 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
7545
(14)
Butylone (bk-MBDB), its optical, positional, and geometric isomers, salts and salts of isomers
7541
(15)
Pentedrone (α-Methylaminovalerophenone; 2-(Methylamino)-1-phenylpentan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
1246
(16)
Pentylone (bk-MBDP; 1-(1,3-Benzodioxol-5-yl)-2-(methylamino)pentan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
7542
(17)
4-Fluoro-N-methylcathinone (4-FMC; Flephedrone; 1-(4-Fluorophenyl)-2-(methylamino)propan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
1238
(18)
3-Fluoro-N-methylcathinone (3-FMC; 1-(3-Fluorophenyl)-2-(methylamino)propan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
1233
(19)
Naphyrone (Naphthylpyrovalerone; 1-(Naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
1258
(20)
alpha-Pyrrolidinobutiophenone (α-PBP; 1-Phenyl-2-(pyrrolidin-1-yl)butan-1-one), its optical, positional, and geometric isomers, salts and salts of isomers
7546
(a)
Schedule II shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the Controlled Substances Code Number set forth opposite it.
(b)
Substances, vegetable origin or chemical synthesis. Unless specifically excepted or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin, or independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis:
(1)
Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate excluding apomorphine, thebaine-derived butorphanol, dextrorphan, nalbuphine, nalmefene, naloxegol, naloxone, and naltrexone, and their respective salts, but including the following:
(2)
Any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of the substances referred to in paragraph (b) (1) of this section, except that these substances shall not include the isoquinoline alkaloids of opium.
(4)
Coca leaves (9040) and any salt, compound, derivative or preparation of coca leaves (including
Cocaine (9041) and
Ecgonine (9180) and their salts, isomers, derivatives and salts of isomers and derivatives), and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include:
(i)
Decocainized Coca leaves or extraction of Coca leaves, which extractions do not contain Cocaine or Ecgonine; or
(5)
Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy).
9670
(c)
Opiates. Unless specifically excepted or unless in another schedule any of the following opiates, including its isomers, esters, ethers, salts and salts of isomers, esters and ethers whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation, dextrorphan and levopropoxyphene excepted:
(5)
Bulk
Dextropropoxyphene (Alpha-(+)-4-dimethylamino-1,2-diphenyl-3-methyl-2-propionoxybutane) (non-dosage forms)
9273
(d)
Stimulants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system:
(1)
Amphetamine, its salts, optical isomers, and salts of its optical isomers
1100
(e)
Depressants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
(f)
Hallucinogenic substances.
(1)
Nabilone ((±)-
trans-3-(1,1-Dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9
H-dibenzo[
b,
d]pyran-9-one)
7379
(g)
Immediate precursors. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances:
(1)
Immediate precursor to Amphetamine and Methamphetamine:
(i)
Phenylacetone (Phenyl-2-propanone; P2P; Benzyl methyl ketone; Methyl benzyl ketone)
8501
(2)
Immediate precursors to Phencyclidine (PCP):
(3)
Immediate precursor to Fentanyl:
(a)
Schedule III shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it.
(b)
Stimulants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous sxstem[sic], including its salts, isomers (whether optical, position, or geometric), and salts of such isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
(1)
Those compounds, mixtures, or preparations in dosage unit form containing any stimulant substances listed in schedule II which compounds, mixtures, or preparations were listed on August 25, 1971, as excepted compounds under Sec. 1308.32, and any other drug of the quantitative composition shown in that list for those drugs or which is the same except that it contains a lesser quantity of controlled substances
1405
(c)
Depressants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system:
(1)
Any compound, mixture or preparation containing:
(iii)
Pentobarbital or any salt thereof and one or more other active medicinal ingredients which are not listed in any schedule.
2271
(2)
Any suppository dosage form containing:
(iii)
Pentobarbital or any salt of any of these drugs and approved by the Food and Drug Administration for marketing only as a suppository.
2271
(3)
Any substance which contains any quantity of a derivative of
Barbituric acid or any salt thereof
2100
(6)
Any drug product containing
Gamma-hydroxybutyric acid (GHB; Gamma-hydroxybutyrate; 4-Hydroxybutyrate; 4-Hydroxybutanoic acid; Sodium oxybate; Sodium oxybutyrate), including its salts, isomers, and salts of isomers, for which an application is approved under section 505 of the Federal Food, Drug, and Cosmetic Act
2012
(7)
Ketamine ((±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone), its salts, isomers, and salts of isomers
7285
(11)
Perampanel, and its salts, isomers, and salts of isomers
2261
(16)
Tiletamine (2-(Ethylamino)-2-(2-thienyl)cyclohexanone) and
Zolazepam (4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-
e][1,4]diazepin-7(1
H)-one; Flupyrazapon) or any salt thereof
7295
(e)
Narcotic Drugs. Unless specifically excepted or unless listed in another schedule:
(1)
Any material, compound, mixture, or preparation containing any of the following narcotic drugs, or their salts calculated as the free anhydrous base or alkaloid, in limited quantities as set forth below:
(i)
Not more than 1.8 grams of
Codeine per 100 milliliters or not more than 90 milligrams per dosage unit, with an equal or greater quantity of an isoquinoline alkaloid of
Opium
9803
(ii)
Not more than 1.8 grams of
Codeine per 100 milliliters or not more than 90 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts
9804
(iii)
Not more than 1.8 grams of
Dihydrocodeine per 100 milliliters or not more than 90 milligrams per dosage unit, with one or more active nonnarcotic ingredients in recognized therapeutic amounts
9807
(iv)
Not more than 300 milligrams of
Ethylmorphine per 100 milliliters or not more than 15 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts
9808
(v)
Not more than 500 milligrams of
Opium per 100 milliliters or per 100 grams or not more than 25 milligrams per dosage unit, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts
9809
(vi)
Not more than 50 milligrams of
Morphine per 100 milliliters or per 100 grams, with one or more active, nonnarcotic ingredients in recognized therapeutic amounts
9810
(2)
Any material, compound, mixture, or preparation containing any of the following narcotic drugs, or their salts as set forth below:
(f)
Anabolic steroids. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture or preparation containing any quantity of the following substances, including its salts, esters and ethers:
(1)
Anabolic steroids (see §1300.01 of this chapter)
4000
From 21 CFR 1300.01 Definitions relating to controlled substances
Anabolic steroid means any drug or hormonal substance, chemically and pharmacologically related to testosterone (other than estrogens, progestins, corticosteroids, and dehydroepiandrosterone), and includes:
(11)
Bolasterone (7α,17α-Dimethyl-17β-hydroxyandrost-4-en-3-one)
(12)
Boldenone (17β-Hydroxyandrost-1,4-diene-3-one)
(13)
Boldione (Androsta-1,4-diene-3,17-dione)
(14)
Calusterone (7β,17α-Dimethyl-17β-hydroxyandrost-4-en-3-one)
(15)
Clostebol (4-Chloro-17β-hydroxyandrost-4-en-3-one)
(23)
Formebolone (2-Formyl-17α-methyl-11α,17β-dihydroxyandrost-1,4-dien-3-one)
(24)
Furazabol (17α-Methyl-17β-hydroxyandrostano[2,3-
c]furazan)
(28)
Mestanolone (17α-Methyl-17β-hydroxy-5α-androstan-3-one)
(29)
Mesterolone (1α-Methyl-17β-hydroxy-[5α]-androstan-3-one)
(33)
Methenolone (1-Methyl-17β-hydroxy-5α-androst-1-en-3-one)
(41)
Mibolerone (7α,17α-Dimethyl-17β-hydroxyestr-4-en-3-one)
(55)
Oxandrolone (17α-Methyl-17β-hydroxy-2-oxa-[5α]-androstan-3-one)
(57)
Oxymetholone (17α-Methyl-2-hydroxymethylene-17β-hydroxy-[5α]-androstan-3-one)
(59)
Stanozolol (17α-Methyl-17β-hydroxy-[5α]-androst-2-eno[3,2-
c]pyrazole)
(60)
Stenbolone (17β-Hydroxy-2-methyl-[5α]-androst-1-en-3-one)
(61)
Testolactone (13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid lactone)
(90)
Any salt, ester, or ether of a drug or substance described in this paragraph. Except such term does not include an anabolic steroid that is expressly intended for administration through implants to cattle or other nonhuman species and that has been approved by the Secretary of Health and Human Services for such administration. If any person prescribes, dispenses, or distributes such steroid for human use, the person shall be considered to have prescribed, dispensed, or distributed an anabolic steroid within the meaning of this paragraph.
(g)
Hallucinogenic substances.
(1)
Dronabinol ((6a
R-
trans)-6a,7,8,10a-Tetrahydro-6,6,9-trimethyl-3-pentyl-6
H-dibenzo[
b,
d]pyran-1-ol; (–)-Delta-9-(
trans)-tetrahydrocannabinol) (synthetic) in sesame oil and encapsulated in a soft gelatin capsule in a U.S. Food and Drug Administration approved product
7369
(a)
Schedule IV shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section. Each drug or substance has been assigned the DEA Controlled Substances Code Number set forth opposite it.
(b)
Narcotic drugs. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation containing any of the following narcotic drugs, or their salts calculated as the free anhydrous base or alkaloid, in limited quantities as set forth below:
(c)
Depressants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
Indiplon (
N-Methyl-
N-[3-[3-(2-thienylcarbonyl)pyrazolo[1,5-
a]pyrimidin-7-yl]phenyl]acetamide)
2726
(d)
Fenfluramine. Any material, compound, mixture, or preparation which contains any quantity of the following substances, including its salts, isomers (whether optical, position, or geometric), and salts of such isomers, whenever the existence of such salts, isomers, and salts of isomers is possible:
(e)
Lorcaserin. Any material, compound, mixture, or preparation which contains any quantity of the following substances, including its salts, isomers, and salts of such isomers, whenever the existence of such salts, isomers, and salts of isomers is possible:
(f)
Stimulants. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers:
(8)
Pemoline (including organometallic complexes and chelates thereof)
1530
(12)
SPA ((–)-1-Dimethylamino-1,2-diphenylethane)
1635
(g)
Other substances. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture or preparation which contains any quantity of the following substances, including its salts:
(3)
Eluxadoline (5-[[[(2
S)-2-Amino-3-[4-aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl][(1
S)-1-(4-phenyl-1
H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid) (including its optical isomers) and its salts, isomers, and salts of isomers
9725
(a)
Schedule V shall consist of the drugs and other substances, by whatever official name, common or usual name, chemical name, or brand name designated, listed in this section.
(b)
Narcotic drugs. Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation containing any of the following narcotic drugs and their salts, as set forth below:
(c)
Narcotic drugs containing non-narcotic active medicinal ingredients. Any compound, mixture, or preparation containing any of the following narcotic drugs, or their salts calculated as the free anhydrous base or alkaloid, in limited quantities as set forth below, which shall include one or more non-narcotic active medicinal ingredients in sufficient proportion to confer upon the compound, mixture, or preparation valuable medicinal qualities other than those possessed by narcotic drugs alone:
(1)
Not more than 200 milligrams of
Codeine per 100 milliliters or per 100 grams.
(2)
Not more than 100 milligrams of
Dihydrocodeine per 100 milliliters or per 100 grams.
(3)
Not more than 100 milligrams of
Ethylmorphine per 100 milliliters or per 100 grams.
(5)
Not more than 100 milligrams of
Opium per 100 milliliters or per 100 grams.
(d)
Stimulants. Unless specifically exempted or excluded or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant effect on the central nervous system, including its salts, isomers and salts of isomers:
(e)
Depressants. Unless specifically exempted or excluded or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts:
(1)
Ezogabine (
N-[2-Amino-4-(4-fluorobenzylamino)phenyl]-carbamic acid ethyl ester)
2746
(2)
Lacosamide ((
R)-2-Acetoamido-
N-benzyl-3-methoxypropionamide)
2779
(3)
Pregabalin ((
S)-3-(Aminomethyl)-5-methylhexanoic acid)
2782
•
Updated 31 August 2016
