Forendex change log for 20 Mar 2016

Design change:

• Following the switch to IDML™ and Unicode the search box now displays names without italics or other formatting when searching by name. Greek letters will always appear “spelled out” when searching by name. In some respects this is perhaps slightly retrograde but there is merit to this change:
  • The matching names are more clearly “in line” with what is typed in the search box, i.e. more WYSIWYG. When searching for “beta” any matching names display as beta, not β or some mixture of each.
  • The alternative would necessitate allowing Greek letters in the search box, which is unwieldy in practice.
  
  In all other places, or when searching by molecular weight, names are displayed as in the original text.

Forendex change log for 14 Mar 2016

Below the radar (read, you don’t need to read this):

• Unicode is now used for substance names, with embedded IDML™ (Isomer Design Markup Language) for presentable typography supplanting HTML. Everything ought to look the same as before. If you spot any of the following suspicious characters stay calm and do not approach them: / # ! ^ and _.
• CSA names on the substance detail pages are sorted alphabetically. Non-CSA names are grouped into primary, secondary and IUPAC, then alphabetically. Alphabetically means without regard to locants, punctuation, or bits in italics, i.e. rationally for a chemical name. The sorting algorithm used is good but not perfect.

Minor design changes:

• Old style structures (static png files) are shown inside a light grey surrounding box.

Data restored:

• Some recently added substances have regained their lost, non-IUPAC names. Curious.

Forendex change log for 21 Feb 2016

Bugs fixed:

• Names in CSA schedules that in places appeared #like this# or #like##this# are again rendered properly, like this and like (this).

Forendex change log for 20 Jan 2016

Due diligence:

• Forendex has a properly installed license for ChemWriter on domain forendex.southernforensic.org.

Forendex change log for 19 Jan 2016

New privilege levels:

• A new privilege level has been created for site administrators. Superuser registration is restricted to administrators.
• The superuser login screen has changed to reflect the new roles, it now prompts more properly for an ID instead of an e-mail address, and superfluous data is no longer displayed.

Bugs fixed:

• Structures rendered by ChemWriter can now be seen using Internet Explorer.

Forendex change log for 18 Jan 2016

New look:

• Forendex has a new icon with deep archetypal meaning (to a bonding orbital):

New data:

• The 19 new substances below have been tagged as recent and classified by category as appropriate.

Bugs fixed:

• Superuser function is restored.

Initiative audit:

• Superusers who have not reported in for over a year are discharged. Thank you for your service.

Forendex change log for 17 Jan 2016

New data:

• The following 19 new substances have been added. This is the first group of compounds to be added using the much-anticipated Forendex dashboard app (still under fevered development). These are also the first structures rendered using the ChemWriter image component. ChemWriter scales the structure to fit the space available—typically the structure will be rendered larger than before (i.e. the old way, using static images).
  • 25I-NBOH
  • 25C-NBOH
  • CUMYL-PICA
  • 5F-CUMYL-PICA
  • EG 018
  • EG2201
  • 5-Methoxy methylone
  • Flubromazepam
  • MDMB-FUBINACA
  • Clonazolam
  • 3-Fluorophenmetrazine
  • PV-7
  • 5F-ADB
  • 5F-AEB
  • Dicalzepam Diclazepam
  • Flubromazolam
  • 4-Bromoamphetamine
  • 5F-ABICA
  • Mexedrone

Design changes:

• To speed page loading and reduce visual clutter IUPAC names are now tagged more succinctly. One can never have too much white space.

Forendex QUASH position vacancy filled:

• The Forendex Distributed Virtual Team is seeking a QUality Assurance SuperHero to squash bugs. Only applicants having hands-on experience with undocumented Forendex features and behaviours will be considered for this unofficial, unpaid, critically important role. Programming experience is not an asset. Preference will be given to candidates with capes. If you spotted the clearly incorrect name in the list of new substances above please step forward. If you spot a second error please call Toronto 320-6975 at once.

Forendex change log for 15 Jan 2016

Design changes:

• The substance detail page background colour has been changed to white. It had been ever so slightly not quite white.

Forendex change log for 11 Jan 2016

New functionality:

• The Standard InChI key on a substance identity page is now a link to whatever Google has found searching for the key.
  Try it! Just to see who’s in the big leagues…
  

Forendex change log for 10 Dec 2015

Below the radar (read, you don’t need to read this):

• The legislative history tab of the CSA schedules page has changed. Previously this page was a “restyled” rendering of a static, external page. Now the page is generated dynamically from the Forendex database. While the page looks the same as before this may improve Forendex system integrity by decoupling the data from the third-party source, an eccentric foreigner. The eccentric foreigner apologizes for the transient denial of service earlier today while the system was being secured.
• The method of displaying structural diagrams has changed. Previously these were saved as a separate .png image file for each substance and were loaded by the browser after the containing page had loaded. The images have since migrated to the Forendex database. Now, a structural diagram may be rendered in one of two ways:
  1. Pre-existing structural diagrams appear as before but are now embedded in the containing page like so…

     <img title="Eluxadoline" src="data:image/png;base64,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">

     which, quite obviously, is rendered as… This method should reduce network bandwidth and speed page loading. In most other regards the two are equivalent.
  2. New structural diagrams are derived from the embedded molfile representation…

       YYZ/Labs08181506532D
     
      42 45  0  0  1  0  0  0  0  0  2 V2000
        85.9923 -167.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        84.8405 -167.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        83.6886 -167.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        82.5368 -167.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        82.5368 -165.8355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        83.6886 -165.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        84.8405 -165.8355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        85.9923 -165.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        87.1432 -165.8355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        88.2950 -165.1706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        88.2950 -163.8407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
        89.4468 -165.8355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
        89.4468 -167.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        87.1432 -167.1653    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
        83.6886 -163.8407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        81.3849 -167.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        81.3849 -169.1601    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
        80.2340 -167.1653    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
        90.5987 -167.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        91.7505 -167.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        92.9014 -167.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        92.9014 -169.1601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        91.7505 -169.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        90.5987 -169.1601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        94.0533 -169.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
        94.0533 -171.1548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        94.0533 -167.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        94.0533 -165.8355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
        95.2051 -167.8302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
        90.5986 -165.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        91.7504 -165.8354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        90.5986 -163.8404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        89.5219 -163.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
        89.9318 -161.7943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        91.6739 -163.0578    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
        91.2619 -161.7932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        89.9318 -159.4907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        89.2668 -160.6425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        89.2668 -158.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        87.9367 -160.6424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        87.9368 -158.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
        87.2718 -159.4906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
       1  2  1  0  0  0  0
       2  3  2  0  0  0  0
       2  7  1  0  0  0  0
       3  4  1  0  0  0  0
       4  5  2  0  0  0  0
       4 16  1  0  0  0  0
       5  6  1  0  0  0  0
       6  7  2  0  0  0  0
       6 15  1  0  0  0  0
       7  8  1  0  0  0  0
       8  9  1  0  0  0  0
       9 10  1  0  0  0  0
       9 14  1  1  0  0  0
      10 11  2  0  0  0  0
      10 12  1  0  0  0  0
      12 13  1  0  0  0  0
      16 17  2  0  0  0  0
      16 18  1  0  0  0  0
      13 19  1  0  0  0  0
      19 20  1  0  0  0  0
      19 24  2  0  0  0  0
      20 21  2  0  0  0  0
      21 22  1  0  0  0  0
      21 27  1  0  0  0  0
      22 23  2  0  0  0  0
      22 25  1  0  0  0  0
      23 24  1  0  0  0  0
      25 26  1  0  0  0  0
      27 28  2  0  0  0  0
      27 29  1  0  0  0  0
      12 30  1  0  0  0  0
      30 31  1  6  0  0  0
      30 32  1  0  0  0  0
      32 33  2  0  0  0  0
      34 33  1  0  0  0  0
      35 32  1  0  0  0  0
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      39 37  2  0  0  0  0
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      38 34  1  0  0  0  0
     M  ZZE  1  32  23
     M  END

     and rendered dynamically in the browser by the ChemWriter image component, like so…

Forendex change log for 20 Nov 2015

Regulatory changes:

• Four recent rules have been added to the CSA legislative history tab and the status of Eluxadoline, 25B-NBOMe, 25C-NBOMe, and 25I-NBOMe adjusted accordingly.

Forendex change log for 23 Sep 2015

Regulatory changes:

• Proposed rule 80 FR 55565 has been added to the CSA legislative history tab: Synthetic Cannabinoid MAB-CHMINACA; Temporary Placement into Schedule I.
• Final rule 80 FR 48044 has been added to the CSA legislative history tab: [123I]Ioflupane; Removal from Schedule II.
• The CSA schedule tabs reflect the above rules.

New/changed data:

• [123I]Ioflupane has shed its proposed tag and MAB-CHMINACA has taken it up along with the usual FR accoutrements. The latter has been known to Forendex for some time.
• About 20 Wikipedia links have been updated to reflect a change in the targeted page. In most cases Wikipedia has simply replaced an initialism with a more descriptive name or embellished the typography with a spot of Greek. One mistaken Wikipedia link has been deleted.

Bugs fixed:

• The CSA History link hover-text on substance detail pages no longer puts hashmarks (#) around substance names. This unforeseeable unforeseen artifact of the changes made 25 July 2015 is now rectified.
• This log was inexplicably injured around that date also, now restored.

Below the radar (read, you don’t need to read this):

• From 80 FR 54715 onward the legislative history table of the Forendex database comes from the Federal Register via the published Application Program Interface (API). The title of the legislation (rule) is different and arguably better, now inverted CAS-index style. Because this is now done programmatically instead of manually there is no possibility of human error ;)
• About 2000 links now connect using HTTP Secure Socket Layer (SSL) protocol. Plainly, https://whatever instead of http://whatever.

Forendex change log for 28 Aug 2015

New data:

• Eluxadoline has been added and tagged as proposed, recent, and unclassified.

Forendex change log for 26 Aug 2015

Regulatory changes:

• Proposed rule 80 FR 48044 has been added to the CSA legislative history tab: Placement of Eluxadoline Into Schedule IV.
• The changes proposed by rule 80 FR 48044 have been added to the CSA Schedule IV tab.
• Eluxadoline remains to be added as a substance; it’s just something about the name…
  • As it appears in the rule:

  5-[[[(2S)-2-amino-3-[4-aminocarbonyl)-2,6-dimethylphenyl]-1-oxopropyl]
  [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino]methyl]-2-methoxybenzoic acid

• More in line with IUPAC 2013:

5-({[(2S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)propanoyl]
[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid

Forendex change log for 25 July 2015

Regulatory changes:

• Final rule 80 FR 42381 has been added to the CSA legislative history tab: Temporary Placement of Acetyl Fentanyl into Schedule I.
• The changes proposed by rule 80 FR 31521 have been added to the CSA Schedule II tab.

New/changed data:

• [123I]Ioflupane, a propsedly uncontrolled substance, has been added for completeness.
• Acetyl Fentanyl is now tagged as USCSA, unclassified and recent.

Forendex change log for 8 June 2015

Regulatory changes:

• Proposed rule 80 FR 31521 has been added to the CSA legislative history tab: Removal of [123I]Ioflupane from Schedule II. [123I]Ioflupane will be added soon, as will the proposed changes to Schedule II of the CSA.

Changed data:

• The recent tag has been clipped off most substances that were added a year or more ago.

New data:

• The new cannabinoids on the block are: MAB-CHMIINACA, PX1, PX2, PX3, MDMB-CHMINACA, FUB-AMB, MA-CHMINACA, MO-CHMINACA and MDMB-CHMICA.
• The other new arrivals are a dodgy lot: 3-Desoxy-3,4-methylendioxypyrovalerone, W-15 (expelled from Wikipedia for Pete’s sake!), β-Hydroxythiofentanyl, 5-MAPB and 5-EAPB.
• Data fill for these substances is sparse.

Other changes:

• More than a few misspelled words in this log have been corrected.

Forendex change log for 28 May 2015

Regulatory changes:

• Proposed rule 80 FR 29227 has been added to the CSA legislative history tab: Temporary Placement of Acetyl Fentanyl into Schedule I.
• Final rule 80 FR 27854 has been added to the CSA legislative history tab: Extension of Temporary Placement of UR-144, XLR11, and AKB48 in Schedule I.
• Proposed rule 80 FR 27611 has been added to the CSA legislative history tab: Placement of UR-144, XLR11, and AKB48 into Schedule I.
• CSA Schedule I has been updated to reflect the above rules.

Other changes (under the hood, finished):

• ALL links from the legislative history tab now lead to federalregister.gov for rules, and to congress.gov for bills or laws, as far back as each website has history. Links to Federal Register pages in .pdf format still lead to gpo.gov though by redirection through federalregister.gov rather than directly. This marks the end of all that fun stuff.

Forendex change log for 12 Apr 2015

Regulatory changes:

• Final rule 80 FR 14842 has been added to the CSA legislative history tab: Substances Temporarily Controlled Under Schedule I of the CSA.
  
  This is a technical rule without substantive effect, merely “housekeeping.” Section (h) of Schedule I expands whenever the emergency scheduling protocol is invoked. Almost without exception scheduling becomes “permanent” before the temporary interval has elapsed. (The sole exception, I believe, was TFMPP. The emergency boosting it from oblivion to Schedule I was uniquely short-lived.)
  
  Temporary scheduling via Section (h) eventually ceases to be “in force.” Typically though the entries remain, ghost-like, often for years. In the fullness of time Section (h) is revisited, the ghosts are cast out, and the rest renumbered consecutively from 1.

Forendex change log for 15 Mar 2015

Status of Forendex after outage:

• Forendex is back up and running. The data has been verified and everything appears to be working properly. External superuser access to Forendex is reinstated. On behalf of Team Forendex™, past and present, I thank you for your patience.

Forendex change log for 14 Mar 2015

Status of Forendex after outage:

• Forendex was offline for several days following the failure of the hosting server. After a successful port to a new hosting server, Forendex was back online by mid-week though marred by a variety of largely spurious error messages that were overly alarmist and highly off-putting. I apologize for all that nonsense, it should never have glazed the eye of any Forendex reader.
  
  Public access to Forendex is, I believe, fully restored. We’re currently checking the Forendex data to ensure nothing was lost. External superuser access to Forendex is temporarily suspended and will be restored as soon as possible. Please bear with us for a little longer.
  
  Agent NT, if ever we needed you… ;)

Forendex change log for 5 Feb 2015

Regulatory changes:

• Final rule 80 FR 5042 has been added to the CSA legislative history tab: Temporary Placement of Three Synthetic Cannabinoids Into Schedule I. The proposed tag has been cleared for these latest additions to Schedule I. The three cannabinoids (AB-CHMINACA, AB-PINACA, and THJ-2201) have been tagged USCSA, cannabinoid and recent.

Forendex joins the Creative Commons:

• In a nod to the collaborative spirit of the internet, Forendex has replaced the copyright mark © at the foot of the page with a creative commons license logo . The gist of this is to foster creative reuse of Forendex data by anyone, provided such reuse:
  • includes attribution (BY),
  • is not for commercial use (NC), and
  • allows further reuse by others, aka share-alike (SA).

Forendex change log for 27 Jan 2015

Bug fixes:

• The number of substances listed in the database statistics on the home page has been corrected. It was somewhat inflated recently.

Changed data:

• The CSA entries that describe controlled cannabinoids in so-called generic terms have been “promoted” and are no longer marked as unofficial. These generic definitions, like the list of anabolic steroids, are not actually part of the schedules of the CSA. They have been “read into” the schedules for convenience.

Forendex change log for 23 Jan 2015

Regulatory changes:

• Final rule 80 FR 3468, Removal of Naloxegol From Control, has been added to the CSA legislative history tab. The schedule II tab has been updated accordingly.
  

New data:

• Naloxegol, a PEGylated naloxol explicitly excluded from control, has been added for completeness. Peculiar cases like this are problematic, and as a result the entry for Naloxegol does not include its scheduling history because, in a sense, it’s not a scheduled substance. This may be addressed in future.

Forendex change log for 18 Jan 2015

New data:

• Three new substances have been added:
  • 3-Bromomethcanthinone (3-BMC), tagged recent,cathinone
  • NM2201, tagged recent,cannabinoid
  • AM2201 8-quinolinyl carboxamide, tagged recent,cannabinoid
  Monographs on these will be available soon from the Forensic Drug Review.

Forendex change log for 13 Jan 2015

Correction:

• My thanks to VC for reporting a transcription error in one of the names for α-PVP, which had read propan-1-one instead of pentan-1-one.

Forendex change log for 10 Jan 2015

Regulatory changes:

• H.R. 4771, Designer Anabolic Steroid Control Act of 2014, which became law 18 Dec 2014, has been added to the CSA legislative history tab. The Act names 25 additional steroids as part of the definition of “anabolic steroid” though two were already controlled and a third is named twice. Still another specifies atypical stereochemistry at position 5. The names have been reproduced almost verbatim (e.g. all are capitalized here though the Act is erratic about capitalization), errors and all, in the CSA Schedule III tab.
• A few entries in the CSA Schedules previously flagged as pending have been cleared, the once future in-force date having long passed.
• Minor changes have been made throughout the CSA Schedules, typically more technical than substantive changes.

New data:

• The 22 truly novel steroids listed in H.R. 4771 have been added. Data fill is incomplete for these substances. IUPAC names are provided. Where ACD/Name was not up to the challenge of naming the substance as a steroid, or omitted any now-mandatory stereochemistry, I’ve supplied an additional name according to the 2013 Blue Book rules. Such names are followed with the notation “(other).”
• The new steroids are tagged USCSA, H.R.4771, and recent. Note there is currently no H.R. 4771 category like the one for S. 3187. Its additions can most easily be seen by clicking on the Recently Added button and sorting the tags column by clicking on the column heading. The H.R. 4771 substances appear as a group near the end of table, in the order they are listed in the Act.

Other notes:

• The Forendex database has been reorganized following an improved design. The interface (i.e. the Forendex website) is unchanged.

Agent NT hangs up her cape:

Finally, it is with… mixed emotions I note the departure of Natalie Thomas, who spent a good part of 2014 scrutinizing Forendex functionality and data quality, becoming the de facto Forendex “acceptance tester” — albeit five years after delivery.

Natalie demonstrated time and again an… uncanny talent for finding subtle data errors and bugs in the code. Forendex is significantly more robust and more accurate as a result. All the best, Natalie, and thank you. It was fun ;)

Forendex change log for 21 Dec 2014

Regulatory changes:

• Proposed rule 79 FR 75767 has been added to the CSA legislative history tab: Temporary Placement of Three Synthetic Cannabinoids Into Schedule I. The CSA schedule row for each of the three substances named in the proposed rule is tagged proposed. The substances are also tagged as proposed.
• Proposed rule 79 FR 64349 has been added to the CSA legislative history tab: Removal of Naloxegol From Control.

Minor cosmetic change to CSA legislative history:

• For consistency only, the title of every proposed rule now has the prefix [Proposed]. Previously some had the prefix [Proposed rule].

Forendex change log for 13 Sept 2014

Regulatory changes:

• Final rule 79 FR 51243 has been added to the CSA legislative history tab: Placement of Suvorexant into Schedule IV.
• The CSA Schedule IV entry for Suvorexant is flagged as controlled pending—Rule 79 FR 51243 takes effect 29 Sept 2014.
• The Suvorexant entry in Section (c) is a bit further down from where I had been mistakenly placed it earlier. The entries that follow Suvorexant in section (c) have been renumbered.

Forendex change log for 22 Aug 2014

Regulatory changes:

• Final rule 79 FR 49661 has been added to the CSA legislative history tab: Rescheduling of Hydrocodone Combination Products From Schedule III to Schedule II.
• The CSA Schedule III entries for Hydrocodone combination products are flagged as awaiting revocation on the effective date of rule 79 FR 49661.

Forendex change log for 20 Aug 2014

Merged data:

• The substances named THJ-018 and JWH-018 indazole analogue have been merged. Thanks to NT for spotting the duplication.

Minor cosmetic change:

• Space filling 3D-depictions of molecules are no longer displayed. It was felt a hundred thousand hours utterly wasted (a conservative aggregate estimate) simply trying to accommodate Java—the celebrated shambles from Oracle Corporation—was enough.
• 3D-depictions may return if a functional replacement from a competent vendor can be found.

Forendex change log for 17 July 2014

Changes to CSA legislative history:

• [Non-geeks can skip this.] All links to extant Federal Register web pages (back to 1 Jan 1994, at present) now point to www.federalregister.gov and conform to their recommendations for linking by FR document number. An FR document number is different from the familiar FR citation of the form xx FR yyyyy. FR citations are well entrenched and satisfactory for most things, being essentially a reference to a (traditional, printed) page within a collection of annual volumes. A single printed page may include more than one amendment however, i.e. an FR citation may not always uniquely identify an amendment. Using FR document numbers instead avoids any ambiguity.

  That said, the legislative history page looks the same as before, FR citations are still displayed, and the links may ultimately point to the same page as before. It’s really just housekeeping, and following best practices.

• During the conversion some incorrect FR citations were found and corrected:
  

  Former citation	Corrected citation
  76 FR 77330	76 FR 77329
  76 FR 40552	76 FR 40551
  75 FR 60196	75 FR 60195
  74 FR 63603	74 FR 63609

• These FR citations were missed previously and have been added to the legislative history only:
  

  Additional citation
  75 FR 67054
  69 FR 16838
  68 FR 14114
  68 FR 4127
  67 FR 47343
  67 FR 47341
  67 FR 20072
  66 FR 51535
  66 FR 51530
  65 FR 17440
  62 FR 27214

Bugs fixed:

• While traversing the schedules of the CSA, agent NT encountered a novel quantum singularity in the Tramadol quadrant. The anomaly was easily collapsed by adjusting the cosmological constant for that region.

Other changes:

• The home page link to Cayman Chemical has been updated.

Forendex change log for 7 July 2014

New data:

• Five new cannabinoids have been added. These can also be found in the “recently added” category.
  • FUB-144
  • FUBIMINA
  • THJ
  • THJ-018 [Later merged with the pre-existing entry: JWH-018 indazole analogue.]
  • THJ-2201

Forendex change log for 2 July 2014

Regulatory changes:

• Final rule 79 FR 37623 has been added to the CSA legislative history tab: Placement of Tramadol Into Schedule IV. The corresponding entry at Schedule IV (b)(3) is flagged as controlled pending.
• Schedule IV (c)(1) entry Alfaxalone is no longer flagged as controlled pending as the effective date for its inclusion, 25 March 2013, has passed.
• Tramadol and Alfaxalone are tagged as USCSA, recent and unclassified.

Forendex change log for 2 June 2014

New and changed data:

• A IUPAC name is provided for every substance. Previously coverage fell short of 100 per cent. The name provided by ACD/Name has been used except for a handful of substances.

Forendex change log for 1 May 2014

Deprecated data:

• All IUPAC-aspiring names provided by ChemSpider when Forendex launched have been removed. The quality of some of these names was suspect. The indicated stereochemistry was frequently at odds with the depiction and/or the IUPAC name provided by ACD/Name. The preferred IUPAC recommendations for naming steroids were not followed.
  
  The consensus was the uncertainty of these names exceeded their utility and the IUPAC name provided by ACD/Name was superior and sufficient. Readers seeking additional IUPAC-ish names are encouraged to peruse the many alternatives ChemSpider and PubChem afford.
  
  My thanks to NT for spurring this improvement to Forendex data quality.

Bugs fixed:

• [This is of interest only to superusers] Link management has been improved. Previously, links to Wikipedia, Erowid, Drugs-Forum and Bluelight were always created when the identity data was modified in any way, even when there was nothing to link to, i.e. the link was empty. This created spurious rows in the links table; harmless but shoddy.
  
  Empty links are no longer saved. An existing link may now be deleted (as opposed to merely erasing the link’s data) by clearing either the URL or the title field before saving.
  
  My thanks to NT for having exposed this inconvenient truth. Repeatedly.
  

Forendex change log for 17 Apr 2014

Changed data:

• The SMILES string for 611 substances has changed. Previously the SMILES string was derived from the Standard InChI string. InChI and SMILES handle tautomers differently and in some cases the derived SMILES did not reflect the depicted tautomer.
  
  Now, the SMILES string is generated directly from the MOL (i.e. connection table) file using Open Babel software. The new SMILES strings are canonical and universal. Hard-core cheminformaddicts are referred to the open access journal article Towards a Universal SMILES representation - A standard method to generate canonical SMILES based on the InChI, Noel M O’Boyle, Journal of Cheminformatics 2012, 4:22 (18 September 2012). doi:10.1186/1758-2946-4-22.
  
  I am indebted to NT for bringing this subtle and pervasive issue to my attention.
  

Forendex change log for 18 Mar 2014

New and changed data:

• 18 new substances have been added. These can also be found in the “recently added” category.
  • 30C-NBOMe
  • 5F-AB-PINACA
  • 5F-AMB
  • 5F-MN18
  • 5F-SDB-005
  • 5F-SDB-006
  • 5F-THJ
  • AB-CHMINACA
  • AMB
  • FUB-PB-22
  • FDU-PB-22
  • JWH-081-N-(cyclohexylmethyl) analogue
  • MN-18
  • MN-25
  • PV8
  • SDB-005
  • SDB-006
  • XLR-12
• Links formerly pointing to Bluelight.ru now point to Bluelight.org, the website’s new and improved domain name.

Corrected data:

• The space-filling (3D) depictions of substances 489–493 and 495–500, mostly anabolic steroids, were egregiously wrong and have been corrected.

Other changes:

• The ordering of code names (e.g. almost any name in the above list) has been further refined and rationalized. The change log for 23 Jun 2013 explains how code names are handled.

Forendex change log for 13 Mar 2014

Regulatory changes:

• Final rule 79 FR 10985 has been added to the CSA legislative history tab: Temporary Placement of 10 Synthetic Cathinones [4-MEC, 4-MePPP, α-PVP, Butylone, Pentedrone, Pentylone, 4-FMC, 3-FMC, Naphyrone and α-PBP] into Schedule I. My thanks to Lee Fadness for the tip.

New and changed data:

• The 10 cathinones are listed at (19) through (28) in section (h) of Schedule I, marked as “USCSA” and the “proposed” tag removed.

Forendex change log for 27 Feb 2014

Regulatory changes:

• Final rule 79 FR 10985 has been added to the CSA legislative history tab: Placement of Alfaxalone into Schedule IV.
• Proposed rule 79 FR 11037 has been added to the CSA legislative history tab: Rescheduling of Hydrocodone Combination Products From Schedule III to Schedule II.

New and changed data:

• Alfaxalone has been tagged as USCSA, unclassified and recent. It is shown as controlled pending since the effective date of the rule is 31 March 2014. Note that while the proposed rule included both a systematic and trivial name, the final rule gives only the latter. Substances that follow Alfaxalone in Schedule IV Section C have been renumbered.
• Hydrocodone scheduling history now includes the proposed revocation of some Schedule III entries. If the proposal is finalized, these “special case” exemptions for Hydrocodone combination products will be struck out, leaving the Schedule II status for Hydrocodone in effect.

Forendex change log for 26 Feb 2014

Corrected data:

• The SMILES string for every substance with defined stereochemistry (roughly 220) has been corrected. I'm not going to point any fingers, but this bug had eight legs.
• The entry for substance 1266 (4-MEC) has been deleted and the data merged with the pre-existing substance 1147.
  
  My thanks to Lee Fadness and NT for finding and reporting the above errors.
  
  
• The stereochemistry for Dextropropoxyphene has been corrected.
• The CSA History annotation for substances scheduled in the original CSA of 1970 has been corrected. An inadvertently dropped consonant escaped the spell checker with unfortunate results.

Forendex change log for 13 Feb 2014

Regulatory changes:

• Proposed rule 79 FR 8639 has been added to the CSA legislative history tab: Placement of Suvorexant into Schedule IV.

New data:

• Suvorexant has been added, tagged as proposed, unclassified and recent.
  

Forendex change log for 10 Feb 2014

Regulatory changes:

• Final rule 79 FR 7577 has been added to the CSA legislative history tab: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I.

New and changed data:

• The four cannabinoids above are no longer tagged “proposed.”
• CSA entries (15) through (18) in section (h) of Schedule I are no longer tagged “pending.”

IUPAC news (for nomenclature junkies only)

• Smashing news nomenclature fanboys! The new Blue Book is here! Hard to believe it’s only been 35 years since the first Blue Book was issued, in 1979. Over 1600 pages that practically turn themselves! Spoiler: A few things have changed… Yep.

Forendex change log for 4 Feb 2014

Corrected data:

• The entry for UR-144 N-heptyl analogue contained incorrect information. The names were correct… pretty much everything else was wrong. The entry mistakenly depicted and described the N-hexyl analogue of UR-144, thought to be unknown. The entry has been corrected to depict and describe the N-heptyl homologue.
  
  My apologies for the oversight, and my thanks to NT, the newest member of the Forendex team. for discovering and reporting the error.

Regulatory notice:

• Notice 78 FR 79465 (from Dec 2013) has been added to the CSA legislative history tab: The Food and Drug Administration (FDA) is requesting interested persons to submit comments concerning abuse potential, actual abuse, medical usefulness, trafficking, and impact of scheduling changes on availability for medical use of 26 drug substances.

Forendex change log for 31 Jan 2014

Regulatory changes:

• Proposed rule 79 FR 4429 has been added to the CSA legislative history tab: Temporary Placement of 10 Synthetic Cathinones [4-MEC, 4-MePPP, α-PVP, Butylone, Pentedrone, Pentylone, 4-FMC, 3-FMC, Naphyrone and α-PBP] into Schedule I.

New and changed data:

• The 10 cathinones proposed for scheduling by 79 FR 4429 have been tagged as “proposed.” Eight Nine of the 10 were “known to Forendex” prior to the ruling. The rest have been added:
  • 4-Methyl-N-ethylcathinone; 4-MEC [Thanks to NT for pointing out 4-MEC was also “known to Forendex” actually]
  • 3-Fluoro-N-methylcathinone; 3-FMC
• The 10 cathinones are listed at (19) through (28) in section (h) of Schedule I, marked as “pending.”
• Many new links to PubChem and ChemSpider have been added.

Other changes:

• A few structures incorporating a pyrrolidine ring have been redrawn according to the de facto “standard.”
• The name “pyrrolidinobutriophenone” has been corrected normalized to “pyrrolidinobutiophenone.” See next item.

IUPAC rant (for nomenclature junkies only). The current, the deprecated, and the just plain wrong:

Many of the names commonly used for cathinones, particularly ”latter-day” cathinones like the ones proposed above, are a real dog’s breakfast.

For instance, butiophenone is not a valid IUPAC name and I suspect never was. I’m guessing it is a recent invention, what linguists call a “back-formation,” patterned after the valid IUPAC name propiophenone. Propiophenone derives from the older, now deprecated name for propanoic acid, propionic acid.

It is easy to see how butiophenone might follow propiophenone as the name for the four-carbon homologue. In fact butyrophenone is the correct name, derived from butyric acid, the deprecated name for butanoic acid.

Similarly, pentiophenone is also incorrect. The deprecated name for the five-carbon homologue (pentanoic acid) is valeric acid, from which derives the correct name valerophenone. The trivial name pyrovalerone, for instance, is a contraction of the deprecated (but still valid) name α-Pyrrolidino-p-methylvalerophenone.

I am indebted to coder extraordinaire Daniel Lowe and his Opsin parser, which makes exploring IUPAC nomenclature if not fun, entertaining at least.

Forendex change log for 10 Jan 2014

Regulatory changes:

• Proposed rule 79 FR 1776 has been added to the CSA legislative history tab: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I

New and changed data:

• The four cannabinoids the above rule proposes to control have been tagged as “proposed.”
• The four cannabinoids are listed at (15) through (18) in section (h) of Schedule I, marked as “pending.”

Forendex change log for 2 Dec 2013

Regulatory changes:

• Final rule 78 FR 72013 has been added to the CSA legislative history tab: Placement of Perampanel into Schedule III

Changed data:

• Perampanel has been tagged as “CSA” and the “proposed” tag removed.

Forendex change log for 15 Nov 2013

Regulatory changes:

• Final rule 78 FR 68716 has been added to the CSA legislative history tab: Temporary Placement of Three Synthetic Phenethylamines Into Schedule I

Changed data:

• 25B-NBOMe, 25C-NBOMe and 25I-NBOMe have been tagged as “CSA” and the “proposed” tag removed.

Forendex change log for 4 Nov 2013

Regulatory changes:

• Proposed rule 78 FR 65923 has been added to the CSA legislative history tab: [Proposed] Placement of Tramadol into Schedule IV

New data:

• Tramadol has been added, tagged as proposed and unclassified. Note that the stereochemistry for this entry is unspecified. That is by design since the intent of the rule is to capture all stereoisomers, not simply those contained in the commercial drug Tramadol.
  
  In fact, the rule actually casts the net even wider to include all “isomeric configurations.” Enumerating the isomers dancing on the head of that pin is left as an exercise for the reader.

Other changes:

• Beginning with this rule, Federal Register web (HTML) pages link to federalregister.gov, an marked improvement over gpo.gov/fdsys in my view. Federal Register pdf pages continue to link to the latter website. Links to previous Federal Register web pages will eventually be redirected as well.

Forendex change log for 22 Oct 2013

Regulatory changes:

• Proposed rule 78 FR 62500 has been added to the CSA legislative history tab: [Proposed] Placement of Perampanel into Schedule III

New data:

• Perampanel has been added, tagged as proposed and unclassified.
  

Forendex change log for 10 Oct 2013

Regulatory changes/retractions:

• Proposed rule 78 FR 61991 has been added to the CSA legislative history tab.
• Well over a year since it passed, the generic cannabinoid definitions contained in Bill S. 3187 apparently continue to vex administrative rule makers. During some recent update I inadvertently let slip into the CSA Schedule I listing a reasonable but unofficial approximation of how they might eventually appear. I have now removed them, restoring proper alignment with the current CSA, as far as I know.
  
  I should point out these generic definitions ostensibly have the full force of law despite their formal absence from the CSA schedules as codified and published in the Federal Register.
  

Changed data:

• 25B-NBOMe, 25C-NBOMe and 25I-NBOMe have been tagged as proposed, the subjects of the above proposed rule.

Forendex change log for 4 Oct 2013

Minor cosmetic change:

• The disclaimer at the foot of the home page has been reformatted to fit on two lines.

Forendex change log for 2 Oct 2013

16 new substances:

• AH-7921
• BB-22
• Acetyl fentanyl
• A-836339
• 2C-B-BZP
• Heptyl UR-144
• Noopept
• 4-AcO-DIPT
• 5F-AB-001
• ADB-PINACA
• 5F-ADB-PINACA
• ADB-FUBINACA
• ADBICA
• 5F-ADBICA
• JWH-018 indazole analogue
• JWH-018 benzoimidazol

Functional and design changes:

• A new category (“recent”) has been created for recently added substances. The list is available from the home page button or from the “categories” drop-down menu found on most pages.
• The home page buttons have been rearranged somewhat to accommodate the new category. Hopefully the benefits over the long term will outweigh any inconvenience at the start.

Forendex change log for 29 Sept 2013

Changed data:

• Fentanyl and its analogues have been redrawn. These had been depicted in an unorthodox fashion to exploit an idiosyncrasy of Canadian drug law which lists all of them together, facilitating easy comparison. Unfortunately, outside of that context they just looked weird and haphazard.
• The legislative history now links to Pubic Law 91-513, the Comprehensive Drug Abuse Prevention and Control Act of 1970, or Controlled Substances Act.
• The scheduling status for Lorcaserin has been updated and it has been removed from the “proposed” category.
  

Functional and design changes:

• The CSA History entry for a substance originally scheduled by Pubic Law 91-513 now links to a local copy of the law.

Forendex change log for 18 Sept 2013

Reclaimed data:

• Access has been restored to all issues of the Microgram Journal. Forendex originally linked to the files and web pages of the DEA. Access was lost following the unanticipated reorganization of the DEA website. To ensure access to this important forensic information is protected against future disruption Forendex now links to secured, local copies of the Microgram Journal.
  
  Note to Third Parties: Do not assume the Microgram Journal URLs are durable; they may well change. Link at your own risk.

Forendex change log for 13 Aug 2013

• A sharp-eyed reader reported the 3D depiction of 5F-NNEI featured a fluoroalkyl chains transecting the naphthalene ring. Whatever its aesthetic charm this is highly unlikely in practice. The bug has been reported to ACD/Labs and the depiction patched to something more likely.

Forendex change log for 27 June 2013

Design changes:

• A disclaimer now appears at the foot of the home page, and some minor formatting changes have been made also.

Forendex change log for 26 June 2013

Bugs fixed:

• The CSA citations appearing on substance identity pages were recently changed to links. In some cases these linked to the wrong schedule (tab) on the CSA page. This has been fixed.
  
  Thanks to Lee Fadness for bringing this to my attention.
  

Forendex change log for 23 June 2013

Functional and design changes:

• The new label for the home page search box is intended as a reminder there are two ways to search: by name, and by nominal MW. The kinda-like-a-link lines beneath the two words indicate only that explanatory hover text will appear when the mouse passes over.
• The former home page link, The Controlled Substances Act, has been relabelled Browse CSA schedules and relocated beside the search box.
• Both of the above now sport the colours of the other links on the home page as opposed to the colours of the captions. I know… only a coder could care less but if it proves even a little more intuitive for even a few more readers, good.
• The grid of category links is rearranged somewhat and includes a new link, All substances, to browse the entire Forendex substance collection. The categories drop down menu list includes the All substances entry also.
  
  With thanks to Nick Hubbard for his suggestions which spurred much of the above.

Changed data:

• In most cases where chemical names are listed in “alphabetical” order all locants and other artifacts of systematic nomenclature are more or less ignored and the sort is based largely on the name’s letters. For instance, 4-Ethyl-2,5-dimethoxy-α-methylbenzeneethanamine is pretty much treated like ethyldimethoxymethylbenzeneethanamine.
  
  For better or worse, some “code” names are handled differently, namely ones that begin with a numeral or Greek locant: 25B-NBOMe, 6-APB, α-PVP, etc. In such cases everything is retained, and when sorted these code names appear ahead of the others since digits and special characters appear ahead of letters in collating order. Code names without any leading locant sort like any other name.
  
  It must be admitted what constitutes a code name is not well defined, but in general terms they contain only digits/Greek and capital letters. A few exceptions are made for common abbreviations like MeO for methoxy, e.g. 5-MeO-DALT is treated as 5meodalt. But, 5-Methoxy-DALT does not make the cut and is treated as methoxydalt.
  
  That’s a lot of palaver for something so picayune but it may explain why a substance sometimes does not appear where you expect it to.
• Spectra types have been cleaned up a bit as a preliminary step towards perhaps replacing the current freeform text field.

Bugs fixed:

• Roughly 1000 names for substances not in Forendex have been removed. These names might have appeared among the "auto-complete" list the search box displays--and possibly to a Page not found (404) error if followed. My apologies to any Forendex readers put off by this oversight.

Forendex change log for 17 May 2013

Functional and design changes:

• For a substance listed in the CSA its location is specified on the identity tab. This citation is now a link leading to the corresponding entry on the CSA schedule page. It should be noted that the CSA schedule pages are constructed dynamically and there may be a discernible lag (ca. 2–3 s) after clicking the link before the schedule page is displayed.
• Links to wiki pages at Drugs-Forum.com and Bluelight.ru are now listed on the substance identity tab. Note that the target of these links may be just a stub (a placeholder page awaiting completion.)

Regulatory changes:

• 78 FR 28738 has been added to the CSA legislative history tab.
• 78 FR 28738: Temporary Placement of Three Synthetic Cannabinoids Into Schedule I.
  
  This rule finalizes the temporary scheduling proposed by 78 FR 21858 with some changes and corrections to the originally proposed substance names.
  

Further notice regarding Java:

• Version 7 update 21 seems to work as well as can be expected, i.e. it doesn’t bring down your machine. The update process is about as appealing as a root canal and in my experience often fails. If you decide to install the new version I would suggest removing any existing version first as this seems to increase the changes of a successful installation.
  
  
  • To uninstall Java: Start | Control panel | Programs and features. Select (click on) Java, then right click and uninstall.
  • To install Java: Visit http://java.com/en/download/index.jsp and hope for the best. Take care to clear any pre-checked boxes to circumvent Oracle’s weasly attempt to saddle your machine with their flabware such as anti-viral software and lame browser toolbar.

Forendex change log for 9 May 2013

Regulatory changes:

• 78 FR 26701 has been added to the CSA legislative history tab.

Forendex change log for 8 May 2013

Regulatory changes:

• 78 FR 26701: Placement of Lorcaserin into Schedule IV.
  
  This final rule creates a new section (e) within Schedule IV for Lorcaserin. Note that although this rule does not come into force until 7 June 2013, the sections of Schedule IV previously designated (e) and (f) have been redesignated (f) and (g). In other words, things are a bit out of sync for a month.

Forendex change log for 25 April 2013

Bugs fixed:

• The regulatory history for Lorcaserin has been corrected.
• The references that had been erroneously associated with category S. 3187 have been cleared.
  
  Thanks to Lee Fadness for bringing these to my attention.

28 new substances:

• Methoxetamine
• 4-Methylbuphedrone
• Etizolam
• Allylescaline
• Demoxepam
• Etaqualone
• Camfetmine
• Phenprobamate
• 4-AcO-DMT
• A-834,735
• A-796,260
• 4-Methyl-AET
• 5-IAI
• DMAA
• 5F-AKB48
• PB-22
• 5F-PB-22
• 5-APDB
• 6-APDB
• PMMA
• 25B-NBOMe
• 25E-NBOMe
• 25D-NBOMe
• AB-PINACA
• AB-FUBINACA
• NNEI
• 5F-NNEI
• RTI-126

Forendex change log for 12 Apr 2013

Regulatory changes:

• 78 FR 21818: Placement of Methylone Into Schedule I.
• 78 FR 21858: [Proposed] Temporary Placement of Three Synthetic Cannabinoids Into Schedule I.
  
  A reminder that temporary scheduling now lasts for two years, and may be extended for an additional year. Also, for two of the three substances 78 FR 21858 proposes to schedule the primary name is, strictly speaking, malformed. These have been faithfully transcribed verbatim.
  

New and changed data:

• Many structural diagrams (largely phenethylamines and friends) have been redrawn according to the de facto “standard.” The old depictions may persist indefinitely due to browser caching—clearing the cache should reveal the updated drawings.
• Several new ChemSpider and PubChem IDs have been added, and some superfluous ones removed. Please bear in mind a PubChem ID may not be a perfect match with respect to stereochemistry, particularly for steroids.
• The CSA schedules have been updated to reflect the above two rules.

Forendex change log for 10 Apr 2013

Design changes:

• The home page font size has been reduced slightly to accommodate longer quick link captions, e.g. SWGDRUG monographs.

Regulatory changes:

• 78 FR 17895: Proposed Placement of Alfaxalone into Schedule IV.

New and changed data:

• Alfaxalone has been added as per proposed rule 78 FR 17895 above.
• Prostanozol and its O-tetrahydropyran-2-yl ether are no longer tagged as steroid esters. References to the CSA have been removed from the latter entry since it is, in fact, not listed therein.
  
  Thanks to Lee Fadness for bringing all of this to my attention.

Forendex change log for 8 Apr 2013

Functional and design changes:

• Home page quick links to Forensic Drug Review and SWGDRUG monographs have been added.

Bugs fixed:

• The CSA scheduling history for Prostanozol has been restored. Thanks to Lee Fadness for noticing its absence.
• The hover text for each quick link has been corrected.

Forendex change log for 7 Apr 2013

Notice regarding Java:

• There is much alarm in the IT press lately about ongoing and potentially serious security flaws in Java. There are two schools of thought on the best defence:
  • Some blithely advise you to simply pull Java from your PC, roots and all, since “hardly anything important needs Java.” This is disingenuous at best.
  • Others accept Java as a necessary evil but insist you keep up with the latest version even as they decry the malware Oracle Corp. tries to foist on your machine during the ponderous installation process (namely an idiotic browser toolbar).
  
  If you remove Java at the very least the jmol program which renders the 3D molecular depictions in Forendex will not work.
  If you install the latest version of Java, SE 7 U17, the jmol program may crash it (Java). In Google Chrome it crashes with some composure; in Internet Explorer it is a train wreck.
  
  Perhaps the best thing right now is to do nothing, but probably better to jettison Java altogether than install SE 7 U17.

Changed data:

• Duplicate entries 1157 and 1172 for 4-Ethylmethcathinone (4-EMC) have been consolidated.
• Duplicate entries 1129 and 1159 for 3′,4′-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) have been consolidated.
• Substance 1124 (MDDMA) has been renumbered 175 for complex geopolitical reasons.
• Substance 1150 (4-MTA) has been renumbered 395 for complex geopolitical reasons.
• The CSA schedule I sections g and h have been properly labelled as per 78 FR 664.

Forendex change log for 6 Jan 2013

• Happy new year, and congratulations on “circumventing” the Mayan Apocalypse.

Regulatory changes:

• 78 FR 664: Establishment of Drug Codes for 26 Substances.
  
  This rule codifies the bulk of the amendments enacted by Bill S. 3187, the Food and Drug Administration Safety and Innovation Act/Synthetic Drug Abuse Prevention Act of 2012 and in force from 9 July 2012. Note that the UK-style “generic” definition of cannabimimetic agents enacted by Bill S. 3187, while in force, are not addressed by this rule.
  

Changed data:

• The 26 substances above are no longer tagged “proposed.”

New data:

• CSA scheduling history and DEA drug code is now included for the 26 substances above.
  

Other changes:

• Rendering of subscripts in molecular formulae is improved.

Forendex change log for 20 Dec 2012

New links to regulatory proposals:

• 77 FR 75075: [Proposed] Placement of Lorcaserin into Schedule IV.

New data:

• Lorcaserin has been added.

Forendex change log for 18 Oct 2012

Regulatory changes:

• 77 FR 64032: Extension of temporary placement of Methylone into schedule I.

Forendex change log for 17 Oct 2012

New links to regulatory proposals:

• 77 FR 63766: [Proposed] Placement of Methylone into Schedule I. This would formally add Methylone, one of three cathinones currently scheduled via the emergency scheduling procedure, to Schedule I. The other two, Mephedrone and Methylenedioxypyrovalerone (MDPV), were added to Schedule I by Bill S. 3187, the Food and Drug Administration Safety and Innovation Act (FDASIA).

Forendex change log for 29 Aug 2012

Changed data:

• The steroids Methasterone and Prostanozol 77 FR 44456 added to the CSA are controlled as of today.

Forendex change log for 25 Aug 2012

Changed data:

• The structural drawings for JWH-145 and JWH-147 have been corrected. The phenyl substituents are now attached at locant 5 of the pyrrol instead of locant 4. InChI, InChI Key and SMILES have been corrected also. My apologies for the error.

Forendex change log for 19 Aug 2012

Changed data:

• The entry for 2-AI (2-Aminoindan) has been corrected. 5-IT had mistakenly been put in its place. Thanks to our alert Forendex reader J.I. for reporting the error.

Forendex change log for 7 Aug 2012

Changed data:

• There is much confusion surrounding the name Prostanozol. The culprit seems to be the World Anti-Doping Agency (WADA), which every year updates their list of Prohibited Substances.
  
  For 2008 (and earlier) it reads: Prostanozol ([3,2-c]pyrazole-5α-etioallocholane-17β-tetrahydropyranol).
  For 2009 (and later) it reads: Prostanozol (17β-Hydroxy-5α-androstano[3,2-c]pyrazole).
  
  Given these names describe distinctly different substances WADA’s explanation, “The nomenclature of Prostanozol has been changed to better follow the International Union of Pure and Applied Chemistry (IUPAC) rules,” seems wanting.
  
  In any case, the latter structure is now listed here under Prostanozol and the former as Prostanozol, O-tetrahydropyran-2-yl and included as a variation of Prostanozol. Thanks to Lee Fadness, Josh Yohannan, and others for solving this mystery.

Forendex change log for 31 July 2012

Changed data:

• The systematic name for Prostanozol given in in 77 FR 44456, 17β-Hydroxy-5α-androstano[3,2-c]pyrazole, seems seriously off the mark. One systematic name for Prostanozol is 17β-((Tetrahydro-2H-pyran-2-yl)oxy)-5α-androst-2-eno[3,2-c]pyrazole. This name has been added to the page for Prostanozol. The name and structure here agree with PubChem, Wikipedia and Toronto Research Chemicals, though the latter lists the 2H-pyrazole tautomer versus the 1H tautomer depicted here.

Forendex change log for 30 July 2012

Regulatory changes:

• Final rule 77 FR 44456 (Classification of Two Steroids, Prostanozol and Methasterone, as Schedule III Anabolic Steroids) published today, comes into effect 29 Aug 2012. This rule now appears in the legislative history for the CSA, and in the two soon-to-be scheduled steroids. The steroids have been marked “controlled pending.” The list of scheduled steroids has been renumbered as per the rule to reflect these additions.

Changed data:

• Prostanozol and Methasterone (see above) are now tagged as steroids; they had been erroneously tagged as steroid esters.

Forendex change log for 23 July 2012

New and changed data:

• The list of new substances added on 1 July 2012 (see below) was incomplete when published but now includes all 70 substances added at that time.
• Names for these new substances have been substantially cleaned up, IUPAC names added where absent, and a couple of corrections made.
• A substance detail page now displays the primary name ahead of secondary and/or IUPAC names, in the page title, and in banner caption. Previously the choice of displayed name was decided by sort order.

Forendex change log for 6 July 2012

New data:

• CAS RNs for the most of the substances added 1 July 2012 have been entered, where known.

Forendex change log for 5 July 2012

Bugs fixed:

• 4-MeO PCP is now tagged as unclassified rather than as a cannabinoid.
• Only Forendex primary names now appear in the substance list for a category. Previously some CSA primary names were displayed as well.
• URB-602 now sorts to its correct position within the cannabinoids category.
• The names of some of the substances added 1 July 2012 have been corrected and/or reordered.

My thanks to Lee Fadness for bringing these bugs to my attention.

Forendex change log for 1 July 2012

Functional and design changes:

• Previously comingled categories have been split up, some have been dropped and new ones added. The home page reflects these changes.
• References can now be attached to categories as well as individual substances.
• Categories now have a two-tabbed page, and references may be attached/detached on the category's references tab just as they would be for a substance.
• Category references appear along with substance-specific references on the references tab for a substance.
• Some statistics now appear on the bottom line of the home page. These are generated on-the-fly and will increase as new records are added.
• A link to Cayman chemical forensic science products has been added to the Quick Links row of the home page.

New legislative/regulatory proposals:

• Bill S. 3187 (Food and Drug Administration Safety and Innovation Act) has been added to the legislative history.

Changes to existing data:

• PubChem IDs have been pruned in an attempt to better match the stereochemistry. A handful of incorrect IDs have been fixed.
• Several dozen CAS RN and Wikipedia links have been added for existing and new substances.
• Tags for Bill S. 839 (Combating Designer Drugs Act of 2011) and H.R. 1254 (Synthetic Drug Control Act of 2011) have been removed, and tags for Bill S. 3187 (Food and Drug Administration Safety and Innovation Act) have been added where appropriate.

70 new substances:

• 5-API (5-IT; 5-(2-Aminopropyl)indole)
• AKB48
• AM-1235
• AM-1241
• AM-2232
• AM-2233
• AM-679
• 2-Aminoindane (2-AI)
• Buphedrone
• CB-13 (CRA-13)
• CB-25
• CB-52
• Dibutylone (bk-DMBDB)
• 3,4-Dimethylmethcathinone (3,4-DMMC)
• Dimethylone (bk-MDDMA)
• 3,4-Dimthylethcathinone (3,4-DMEC)
• 4-Ethyl-N,N-dimethylcathinone (EDMC)
• 4-Ethylethcathinone (4-EEC)
• 4-Ethylmethcathinone (4-EMC)
• 4-Ethylmethcathinone (4-EMC)
• Ethylphenidate
• Eutylone
• 4-Fluoroethcathinone (4-FEC)
• 4-Fluoroisocathinone
• 4-Hydroxy DIPT (4-HO-DIPT)
• 4-Hydroxy MET (4-HO-MET)
• JWH-007
• JWH-011
• JWH-015
• JWH-016
• JWH-018 adamantyl analogue (AB-001)
• JWH-018 adamantyl carboxamide analogue
• JWH-020
• JWH-030
• JWH-031
• JWH-072
• JWH-073 2-methylnaphthyl analgoue
• JWH-073 4-methylnaphthyl analgoue
• JWH-122 4-pentenyl analogue
• JWH-145
• JWH-147
• JWH-175
• JWH-180
• JWH-182
• JWH-249
• JWH-307
• JWH-309
• JWH-368
• JWH-369
• JWH-370
• JWH-424
• MAM-2201 (JWH-122 5-fluoropentyl analogue)
• Methiopropamine
• 3′,4′-Methylenedioxy-α-pyrrolidinobutiophenone (MDPBP)
• 3′,4′-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP)
• 4′-Methyl-α-pyrrolidinobutanophenone (MPBP)
• 4′-Methyl-α-pyrrolidinohexanophenone (MPHP)
• 4′-Methyl-α-pyrrolidinopropiophenone (MPPP)
• NEB (N-Ethylbuphedrone)
• α-PBP (α-Pyrrolidinobutriophenone)
• Pentedrone
• RCS-4 C4 homologue
• STS-135
• UR-144
• URB-597
• URB-602
• URB-754
• XLR11
• XLR11 4-pentenyl analogue

Forendex change log for 5 Mar 2012

New substances:

• AM-1248, JWH-022 and 4-MeO-PCP have been added.

Forendex change log for 1 Mar 2012

New links to legislative/regulatory proposals:

• 77 FR 12508: [Proposed] Placement of Five Synthetic Cannabinoids Into Schedule I.
  
  This would add to Schedule I the same five cannabinoids currently there temporary through the emergency scheduling procedure. Some stereochemical designations have been removed as have the explicit inclusion of the optical, positional, and geometric isomers, salts and salts of isomers.
  
  
• 77 FR 12201: Extension of Temporary Placement of Five Synthetic Cannabinoids Into Schedule I of the Controlled Substances Act.
• 77 FR 4228: Technical Amendments and Corrections to DEA Regulations.
  
  The chief consequence of this amendment as far as Forendex is concerned is to renumber and correct some largely inconsequential typographical errors in the chemical names of anabolic steroids. These are not actually enumerated in CSA Schedule III as set out here, but in the definition of the term “Anabolic steroids.” In fact, the names here were for the most part already, if unwittingly, correct.

Forendex change log for 20 Feb 2012

Bugs fixed:

• Saving new or modified rows now works properly with Internet Explorer.

Forendex change log for 3 Feb 2012

Bugs fixed:

• The references page table has been reined in to fit the size of the display.

New substances:

• 4-FA, 4-FMA, 4-MEC and 4-MTA have been added.

Forendex change log for 29 Jan 2012

Bugs fixed:

• The file upload prompt asking for confirmation before overlaying an existing file now does what it’s told when you opt to cancel the upload.
• Similarly, clicking the cancel button to cancel changes made to a new or existing row in a table now does what it’s told.
• Attempts to delete a row from a table that would cause the loss of unsaved changes in another row now triggers a confirmation prompt.
• Attempts to add an empty row to a table are now ignored whenever possible.
• The confirmation message displayed after a file is successfully uploaded now fades and vanishes after five seconds.

Forendex change log for 4 Jan 2012

New substances:

• 25I-NBOMe and 25C-NBOMe have been added.

Other changes:

• A link to the Forendex Forum has been added to the home page and to the foot of every Forendex page. The Forum opens in a new page or window.

Forendex change log for 21 Dec 2011

Bugs fixed:

• The entry for BZP has been repaired and all the pertinent data is visible again. My thanks to Lee Fadness for alerting me.
• Several mortifying spelling errors on this page have been corrected.

Forendex change log for 17 Dec 2011

General notes:

• Links to the Federal Register are being updated as a result of a reorganization of the GPO’s online holdings. Some links may fail while this update is underway as there are many links that need to be changed and the process cannot be automated.

New/changed substances:

• The status of Carisoprodol has been changed to pending from proposed as per 76 FR 77330.
• The status of Ezogabine has been changed to controlled from proposed as per 76 FR 65424.

New links to regulatory rules:

• 76 FR 77330: Placement of Carisoprodol Into Schedule IV.
• 76 FR 65424: Placement of Ezogabine Into Schedule V.

Forendex change log for 25 Nov 2011

New/changed substances:

• Added Methasterone with tags proposed, steroid ester.
• Added Prostanozol with tags proposed, steroid ester.
• Prostanozol and Methasterone have been added to Schedule III as proposed by 76 FR 72355.

New links to legislative/regulatory proposals:

• 76 FR 72355: [Proposed] Classification of Two Steroids, Prostanozol and Methasterone, as Schedule III Anabolic Steroids

Forendex change log for 3 Nov 2011

New/changed substances:

• The status of the three cathinones whose control had been proposed by 76 FR 55616 has been changed to controlled from pending as per 76 FR 65371 published 21 Oct 2011. The legislative history of the three cathinones, and the CSA schedules, have been updated accordingly.
• Ezogabine has been added to Schedule V as proposed by 76 FR 65424.

New links to legislative/regulatory proposals:

• 76 FR 65424: [Proposed] Placement of Ezogabine Into Schedule V.
• 76 FR 65371: Temporary Placement of Three Synthetic Cathinones Into Schedule I.

Forendex change log for 10 Sept 2011

New links to legislative/regulatory proposals:

• 76 FR 55616: [Proposed] Temporary Placement of Three Synthetic Cathinones Into Schedule I.
• 76 FR 40552: Denial of Petition To Initiate Proceedings To Reschedule Marijuana.
• 76 FR 39039: [Proposed] Establishment of a New Drug Code for Marihuana Extract.
• S. 839: Combating Designer Drugs Act of 2011.
• H.R. 1254: Synthetic Drug Control Act of 2011.

New/changed substances. These now appear as proposed additions to the CSA schedules:

• Added Marihuana Extract with tags: cannabinoid; proposed.
• 3,4-Methylenedioxy-N-methylcathinone (Methylone): Added tag: proposed. Re-ordered the names to align with the proposed rule.
• 4-Methyl-N-methylcathinone (Mephedrone) Added tag: proposed. Re-ordered the names to align with the proposed rule.
• 3,4-Methylenedioxypyrovalerone (MDPV): Added tag: proposed. Re-ordered the names to align with the proposed rule.

Bugs fixed:

• Fixed a minor typo in the previous change log entry.

Forendex change log for 22 June 2011

General notes:

• Almost 50 new substances have been added, including:
  • Each substance explicitly named in H.R. 1254, “Synthetic Drug Control Act of 2011.” These have been tagged H.R.1254.
  • Each substance explicitly named in S. 839, “Combating Designer Drugs Act of 2011.” These have been tagged S.839.
  • Other substances of interest selected by SAFS.
• In addition to the above legislative tags, each substance is also tagged following the established classification (cannabinoid, tryptamine, etc.)
• Two new tag have been added: benzodiazepine and indane. These tags have not yet been applied to preexisting substances.
• Over 100 new links to Erowid and Wikipedia have been added.

Bugs fixed:

• If a URL contains an unknown substance id the reader is shown a “404 Page Not Found” screen instead of a crash.

Known issues:

• Your browser may require an updated Java plug-in/extension/add-on.
  • If you are using Google’s Chrome browser it will tell you as much, and provide at least some help with getting the upgrade installed.
  • If you are using Microsoft’s Internet Explorer browser it will likely crash in a most graceless and anxiety-inducing manner, declining to offer jot one of explanation or assistance. Singularly feckless, even by Microsoft’s standards.
• CAS registry numbers, some links, the benzodiazepine tag, and some chemical names generated by ACD/Name remain to be added.

New substances added:

• α-PPP
• α-PVP
• 2C-B-FLY
• 2C-C
• 2C-D
• 2C-E
• 2C-H
• 2C-I
• 2C-N
• 2C-P
• 2C-T-2
• 2C-T-4
• 3C-B-FLY
• 5-APB
• 5-MeO-DALT
• 6-APB
• AM-1220
• AM-2201
• AM-694
• Bromo-DragonFLY
• Dimethylcathinone
• Drostanolone enanthate
• Ethcathinone
• Ethylone
• Flephedrone
• JWH-019
• JWH-098
• JWH-122
• JWH-203
• JWH-210
• JWH-251
• JWH-251
• MBDB
• MBZP
• mCPP
• MDAI
• MDDMA
• MDPPP
• MeOPP
• 5-Methoxy-α-methyltryptamine
• Mitragynine
• MOPPP
• Naphyrone
• Pentylone
• pFPP
• Phenazepam
• Pravadoline
• RCS-4
• RCS-8

Forendex change log for 23 May 2011

Updated data:

• The status of Listed Chemical Ergocristine has been changed to controlled from pending as per 76 FR 17778 published 2 May 2011. The legislative history of Ergocristine and the CSA have been updated accordingly.
• The CAS RN for Hydromorphinol has been changed to 2183-56-4 from 218-356-4.
• CAS RN added for 19-Nor-5-androstenedione.

Other minor changes:

• The width of the CAS RN has increased to 12 from 11, allowing for Mephedrone's 10-digit RN to be stored in the traditional form: nnnnnnnnn-yy-z.
• The checksum digit has been verified for all CAS RNs.
• Some ergolines have had the TiHKAL tag removed if their connection to the book is tenuous, e.g. Ergocristine.

Forendex change log for 22 Mar 2011

Bugs fixed:

• The spelling of the steroid ester 5-Androstenediol dipropionate is now correct. My sincere thanks to the sharp-eyed reader who reported the mistake, and to Lee Fadness for alerting me. This is ”crowd sourced“ data quality control in action.

Forendex change log for 16 Mar 2011

Bugs fixed:

• The pages for two recently scheduled cannabinoids (CP–47,497, CP–47,497 C8 homologue) are again fully functional. My apologies to any readers who were frustrated, and my thanks to Lee Fadness for alerting me.
• The change log link once again opens in a new window/tab.

Other changes:

• The Isomer Design link now opens in a new window/tab.

Forendex change log for 4 Mar 2011

Updated data:

• Status of five synthetic cannabinoids changed to controlled from pending as per 76 FR 11075 published 1 Mar 2011, specifically
  1. 5-(1,1-Dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol, its optical, positional, and geometric isomers, salts and salts of isomers (Other names: CP–47,497)
  2. 5-(1,1-Dimethyloctyl)-2-[(1R,3S)-3-hydroxycyclohexyl]-phenol, its optical, positional, and geometric isomers, salts and salts of isomers (Other names: cannabicyclohexanol and CP–47,497 C8 homologue)
  3. 1-Butyl-3-(1-naphthoyl)indole, its optical, positional, and geometric isomers, salts and salts of isomers (Other names: JWH–073)
  4. 1-[2-(4-Morpholinyl)ethyl]-3-(1-naphthoyl)indole, its optical, positional, and geometric isomers, salts and salts of isomers (Other names: JWH–200)
  5. 1-Pentyl-3-(1-naphthoyl)indole, its optical, positional, and geometric isomers, salts and salts of isomers (Other names: JWH–018 and AM678)

Forendex change log for 22 Feb 2011

Minor cosmetic changes:

• The Publication column of the Legislative History tab has been widened to accommodate the data.

Additional data:

• 75 FR 66196 (a proposed rule, dated 27 Oct 2010, placing Propofol in Schedule IV), previously absent from the Legislative History has been added.
• Propofol has been added to the Schedule IV Section c of the CSA as a proposed addition. My thanks to Lee Fadness for reporting the omission.

Forendex change log for 20 Jan 2011

Bugs fixed:

• A page title (i.e. the text displayed at the top of a browser window) containing a substance name with italic letters (e.g. 5-Methoxy-N,N-dimethyltryptamine) did not display properly. Page titles now display without italics.

Updated data:

• Status of 5-MeO-DMT changed from pending to controlled.
• Schedule I Section (d) Subsections 15 through 34 renumbered owing to the insertion of 5-MeO-DMT as Subsection 15.

Forendex change log for 13 Jan 2011

Bugs fixed and data errors corrected:

• Tiletamine formula, masses, InChI, InChIKey and SMILES were incorrect (Zolazepam values were used instead.)
• Zolazepam nominal mass was incorrect. The fault was using 18 as the nominal mass of Fluorine instead of 19. Regrettably, this error resurfaced in each substance containing Fluorine, for a total of 13 in Forendex.
• KMnO₄ nominal mass was incorrect. Same cause as above: the Potassium nominal mass used was 40 instead of 39. There are no other Potassium containing substances in Forendex.
• The secondary names for 4-Methylaminorex were scrambled up.

Additional and updated data:

• An ACD/Name generated name has been added for most substances.
• All chemical names have been reformatted to follow IUPAC rules regarding italicized elements:
• Lower case letters in ring-fusion names
• Single letter short forms for ortho-, meta- and para-
• Element symbols (O, N, P, S)
• Indicated hydrogen (1H)
• Stereodescriptors (R, S, E, Z, cis-, trans-)
• Various prefixes and their short forms (sec-, tert-, vic-)
• All chemical names have been capitalized and the sort algorithm improved. Names are sorted as if all locants and italicized parts are shifted to the end of the name and all punctuation removed, leaving only letters at the front of the name.
  For instance,
  (3R)-3-Methyl-4-morpholino-2,2-diphenyl-1-pyrrolidin-1-yl-butan-1-one sorts as if it were:
  methylmorpholinodiphenylpyrrolidinylbutanone 3r3422111.
• The Schedules and Legislative History are now current and include proposed changes or additions. These entries are marked with a background colour and have explanatory hover text.
• Some additional CAS registry numbers are included.
• The following structural diagrams were added (or redrawn to be consistent with the Forendex conventions):

• 365	Ergotamine
  424	Ergocristine
  590	Fospropofol
  591	5-Methoxy-N,N-dimethyltryptamine
  1091	MDPV
  1094	Methylone
  1095	JWH-200
  1095	1-[2-(4-Morpholinyl)ethyl]-3-(1-naphthoyl)indole